Endocrine Abstracts

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

Aim: Diabetes mellitus is a chronic metabolic condition characterised by persistent hyperglycaemia with resultant morbidity and mortality related primarily to its associated microvascular and macrovascular complications In this study our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus (T2DM) patients.Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and...

Introduction: Despite the relation between Type 2 Diabetes Mellitus (DM) and development of malignancy is well known, data on antidiabetic drugs and cancer risk is contradictory. Thesis which have suggested that analogue insulins, especially glargine, increase cancer risk, has not been validated. The present study aimed to evaluate the possible contributions of diabetes durations and medications to the type and course of malignancy in patients with both diabetes and malignancy...

Introduction: Diabetic retinopathy (DR) is a vision threatening chronic microvascular complication of diabetes mellitus (DM). The potential roles of GH and insulin-like growth factor 1 (IGF1) in DR have been evaluated in vitro and in vivo. The present study aimed to assess the frequency and severity of retinopathy in acromegalic patients with various disease activity and glucose tolerance states (GTS).Methods: All acromegalic patients follo...

Aim: The present study aimed to investigate the relationship of visceral fat accumulation with the existence of the carotid plaque in ischemic stroke patients.Materials and methods: Seventy patients (37 male, 33 female) with acute ischemic stroke were enrolled in the study. The carotid IMT and the existence of carotid plaque of the patients were evaluated by high resolution ultrasonography with a 7.5 MHz linear superficial array probe in B-mode. The abdo...

A 49-year-old man with history of nodular goitre operation was referred to our clinic because of MTC in postoperative pathology. He had hypertension, postoperative hypothyroidism, no family history of thyroid carcinoma and sudden death. Laboratuary investigations showed high level of calcitonin (C) (763 pg/ml; normal<150), Carcino embryogenic antigen (CEA) (175 ng/ml; normal<2.5), normal thyroid function tests, parathormone, urinary catecholamines. Ser904 polymorphism ...

Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.Design: Prospective case-control study.Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.Meas...

Aim: Comparison of the parameters of obesity with the newly-defined adipocytokines in females applying to our clinic for obesity.Method: Demographical data of 36 obese females were determined. Cases were classified as obese and morbid obese according to BMI values. Biochemical parameters were measured for all the cases. Thicknesses of subcutaneous and visceral fatty tissues were measured on ultrasonography. Statistical significances were evaluated by app...

Background: Thyroid diseases are commonly encountered in the population though it is unanswered for whom screening tests are useful. We aimed to see the value of TSH screening and to find out comorbidities of any thyroid diseases among these patients who were diagnosed by screening.Method: All consecutive patients (n: 796) who admitted to outpatient Clinics of Internal Medicine, between 1 and 31 January 2007 were recruited in the study. Age, gende...

Thyroid dysfunction is associated with altered levels of several coagulation factors. The aim of this study is to investigate the effect of levothyroxine suppression therapy for benign thyroid nodules on coagulation system.Thirty-six patients with benign thyroid nodules, who were applicant for levothyroxine suppression therapy, were included in the study. Thirty patients completed 1 year follow-up period. Levothyroxine was given to maintain TSH level bet...